ISSN 0976 -3090 (Print), 2231- 0541 (Online) PHARMANEST
PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF MENTHA ARVENSIS L. LEAVES ON HALOPERIDOL INDUCED EXTRAPYRAMIDAL MOVEMENT DISORDERS IN ALBINO RATS
BASINI JYOTHI 2*, S. JAGADEESH 1, K. ANUSHA NAIDU 1, S. BANERJEE KUMAR 1, B. LAKSHMI KEERTHI1, S. MOHANA LASKSHMI 1
1. Sree Vidyanikethan College of Pharmacy, A. Rangampet, Chandragiri Mandal, Chittoor Dist, A.P, INDIA
2. Krishna Teja Pharmacy College, Chadalawada Nagar, Renigunta Road, Tirupathi, Chittoor Dist, A.P, INDIA
ABSTRACT Anti-psychotics are the drugs used to treat schizophrenia. Typical anti-psychotics like haloperidol produce serious side effects called extrapyramidal movement disorders (EPS), leading to patient noncompliance and loss of quality of life. These EPS are due to pro-oxidant property of haloperidol which causes oxidative stress induced neuronal damage. So, by the use of anti-oxidants EPS can be reduced. Leaves of Mentha arvensis L. are found to possess anti-oxidant properties. So the main objective of this study is to assess the effect of methanolic extract of Mentha arvensis L. (MEMA) on haloperidol induced adverse effects in albino rats. In the present study, EPS are induced in four groups of albino rats by treating with haloperidol for 21 days, at a dose of 1mg/kg I.P. On the 22nd day three groups of albino rats were treated with MEMA 200mg/kg, 400mg/kg, 600mg/kg respectively. After 30 minutes of administration haloperidol was injected. The fourth group was treated with haloperidol alone. The therapeutic effect of MEMA on haloperidol induced adverse effects was determined by various methods and comparing the (Haloperidol + MEMA) treated groups with Haloperidol treated group. High dose of MEMA showed a beneficiary effect by reducing the haloperidol induced adverse effects in albino rats. Thus, supplementation of MEMA along with haloperidol showed a protective effect over oxidative stress induced neuronal damage in albino rats.
KEYWORDS: Anti psychotics, Haloperidol, Extrapyramidal movement disorders (EPS), Oxidative stress, MEMA.
PHARMANEST - An International Journal of Advances In Pharmaceutical Sciences Vol.2 (2 - 3)
March – June -2010 www.pharmanest.net 179-188